• Gang Zhou
    • Professor
    • Phone No: 027-87686227
    • E-mail: zhougang@whu.edu.cn

    Departments

    Research Field

              Prevention, treatment and etiology of oral mucosal diseases

              Immunological pathogenesis of oral lichen planus

              Carcinogenesis of oral potentially malignant disorders 

    Education

    Ph.D. candidate, from September 2000 to June 2004, Majored in Oral Medicine

    Postgraduate student for a Master’s degree, from September 1989 to June 1992, Majored in Oral Medicine

    Undergraduate student, from September 1984 to June 1989

    Oversea Study and Visit

    October 2005—September 2006   King's College London, London University, U.K.

    Visiting Scholar 

    Honors and Awards

     National Nature Science Foundation of China. Autophagy in T cells of oral lichen planus and its regulation mechanism. 81371147

    National Nature Science Foundation of China. Regulation of inflammation-associated microRNA on CD4+ T cells in oral lichen planus. 81170972

    National Nature Science Foundation of China. Negative regulation of B7-H1/PD-1 pathway on T cells in oral lichen planus. 30973311

    National Nature Science Foundation of China. Polarization of helper T cells in oral lichen planus and its immune intervention. 30572041

    National Health and Family Planning Commission Industry Research Special Funds for Public Welfare Projects. Multicenter collaborative study on new system for early diagnosis of oral potential malignant disorders. 201502018.

    Publications

    1.       Tan YQ, Zhang J, Zhou G*. Autophagy and its implication in human oral diseases. Autophagy. 2017;13(2):225-236.

    2.       Zhang J, Tan YQ, Wei MH, Ye XJ, Chen GY, Lu R, Du GF, Zhou G*. TLR4-induced B7-H1 on keratinocytes negatively regulates CD4+ T cells and CD8+ T cells responses in oral lichen planus. Exp Dermatol. 2017;26:409-415

    3.      Yang JG, Lu R, Ye XJ, Zhang J, Tan YQ, Zhou G* . Icaritin Reduces Oral Squamous Cell

     Carcinoma Progression via the Inhibition of STAT3 Signaling. Int J Mol Sci. 2017 Jan 12;18(1). pii: E132. doi: 10.3390/ijms18010132.

    4.       Han X, Zhang J, Tan Y, Zhou G*. Probiotics: A non-conventional therapy for oral lichen planus. Arch Oral Biol. 2017;81:90-96.

    5.       Peng Q, Zhang J, Ye X, Zhou G*. Tumor-like microenvironment in oral lichen planus: evidence of malignant transformation? Expert Rev Clin Immunol. 2017;13(6):635-643.

    6.       Zhang N, Zhang J, Tan YQ, Du GF, Lu R, Zhou G*. Activated Akt/mTOR-autophagy in local T cells of oral lichen planus. Int Immunopharmacol. 2017;48:84-90.

    7.       Tan YQ, Li Q, Zhang J, Du GF, Lu R, Zhou G*.Increased circulating CXCR5+ CD4+ T follicular helper-like cells in oral lichen planus. J Oral Pathol Med. 2017 Jan 25. doi: 10.1111/jop.12550. [Epub ahead of print]

    8.       Ye X, Zhang J, Lu R, Zhou G*. Signal regulatory protein α associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages. Oncotarget. 2016;7(49):81305-81321.

    9.       Tan YQ, Zhang J, Du GF, Lu R, Chen GY, Zhou G*. Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features. Mediators Inflamm 2016; 2016:4867368.

    10.  Yang JG, Sun YR, Chen GY, Liang XY, Zhang J, Zhou G*.  Different Expression of MicroRNA-146a in Peripheral Blood CD4+ T Cells and Lesions of Oral Lichen Planus. Inflammation. 2016;39(2):860-6

    11.  Zhang J, Wei MH, Lu R, Du GF, Zhou G*.  Declined hTERT expression of peripheral blood 

    CD4+ T cells in oral lichen planus correlated with clinical parameter. J Oral Pathol Med. 

    2016;45(7):516-22.

    12.   Hu JY, Zhang J, Ma JZ, Liang XY, Chen GY, Lu R, Du GF, Zhou G*. MicroRNA-155-IFN-γ Feedback Loop in CD4+ T Cells of Erosive type Oral Lichen Planus. Sci Rep. 2015;5:16935.

    13.   Ye X, Zhang J, Tan Y, Chen G, Zhou G*. Meta-analysis of two computer-assisted screening methods for diagnosing oral precancer and cancer. Oral oncol 2015, 51(11):9.966-975.

    14.   Lu R, Zhang J, Sun W, Du G, Zhou G*. Inflammation-related cytokines in oral lichen planus: an overview. J Oral Pathol Med. 2015;44:1-14.

    15.   Lu R, Zeng X, Han Q, Lin M, Long L, Dan H, Zhou G, Chen Q*. Overexpression and selectively regulatory roles of IL-23/IL-17 axis in the lesions of oral lichen planus. Mediators Inflamm. 2014;2014:701094.

    16.   Ye X, Zhang J, Lu R, Zhou G*. HBO: A possible supplementary therapy for oral potentially malignant disorders. Med Hypotheses. 2014;83(2):131-6.

    17.   Hu JY, Zhang J, Cui JL, Liang XY, Lu R, Du GF, Xu XY, Zhou G*. Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus. Cytokine. 2013;62:141-145.

    18.   Du GF, Li CZ, Shang SH, Xu XY, Chen HZ, Zhou G*. Practising case-based learning in oral medicine for dental students in China. Eur J Dent Educ. 2013; 17(4):225-228.

    19.   Zhou G*, Zhang J, Ren XW, Hu JY, Du GF, Xu XY. Increased B7-H1 expression on peripheral blood T cells in oral lichen planus correlated with disease severity. J Clin Immunol. 2012;32(4):794-801.

    20.   Zhang J, Zhou G*. Green tea consumption: an alternative approach to managing oral lichen planus. Inflamm Res. 2012;61(6):535-539.

    21.   Liu C, Zhou Z, Liu G, Wang Q, Chen J, Wang L, Zhou Y, Dong G, Xu X, Wang Y, Guo Y, Lin M, Wu L, Du G, Wei C, Zeng X, Wang X, Wu J, Li B, Zhou G*, Zhou H*. Efficacy and safety of dexamethasone ointment on recurrent aphthous ulceration. Am J Med. 2012;125(3):292-301.

    22.   Zhang J, Zhou G*, Du GF, Xu XY, Zhou HM. Biologics, an alternative therapeutic approach for oral lichen planus. J Oral Pathol Med. 2011;40(7):521-524.

    23.   Lu R, Zhou G*, Du G, Xu X, Yang J, Hu J. Expression of T-bet and GATA-3 in peripheral blood mononuclear cells of patients with oral lichen planus. Arch Oral Biol. 2011;56(5):499-505.

    24.     Lu R, Dan H, Wu R, Meng W, Liu N, Jin X, Zhou M, Zeng X, Zhou G*, Chen Q*. Lycopene: features and potential significance in the oral cancer and precancerous lesions. J Oral Pathol Med. 2011;40(5):361-368.

    25.     Wu Y, Zhou G, Zeng H, Xiong CR, Lin M, Zhou HM*. A randomized double-blind, positive-control trial of topical thalidomide in erosive oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):188-195.  

    26.   Zhou G*, Xia K, Du GF, Chen XM, Xu XY, Lu R, Zhou HM. Activation of nuclear factor-kappa B correlates with tumor necrosis factor-alpha in oral lichen planus: a clinicopathologic study in atrophic-erosive and reticular form. J Oral Pathol Med 2009, 38: 559-564.

    27.   Xiong C, Li Q, Lin M, Li X, Meng W, Wu Y, Zeng X, Zhou H*, Zhou G*. The efficacy of topical intralesional BCG-PSN injection in the treatment of erosive oral lichen planus: a randomized controlled trial. J Oral Pathol Med 2009, 38: 551-558.

    28.   Xu H, Peng J, Tang HW*, Li Y, Wu QS, Zhang ZL, Zhou G*, Chen C, Li Y. Hadamard transform spectral microscopy for single cell imaging using organic and quantum dot fluorescent probes. Analyst, 2009,134(3):504-511.