• Guobin Yang
    • Associate Professor, DDS,PhD
    • Phone No: 027-87686233
    • E-mail: Guobin.yang@whu.edu.cn

    Departments

    Research Field

    ·Molecular mechanisms of early tooth development

    ·Molecular regulation of later odontobalsts differentiation

    ·Dental pulp regeneration

     

    Education

    ·  Ph.D. candidate, from July 2004 to July 2009, Majored in Endodontics, Supervised by Prof. Xuedong Zhou

            · Undergraduate student, from September 1999 to July 2004

     

    Oversea Study and Visit

    ·  May 2008—June 2009 The University of Texas Health Science Center at San Antonio, Postdoctor

    ·  February 2012 — December 2014  Tulane University, Postdoctor.

     

    Honors and Awards

    ·National Nature Science Foundation of China. Positive and negative regulation of dental epithelial cell proliferation by TGF-β-acticated Smad1/5 and Smad2/3 signaling pathways during early tooth development. 81570942.

    ·National Nature Science Foundation of China. The different function of BMP-MAPK and BMP-Smad1/5 signaling pathway in epithelium and mesenchyme during early tooth development.  81371105 

    ·National Nature Science Foundation of China.  Molecular mechanism of BMP2 induced DLX3 expression and nuclear translocation in odontoblasts 81000418

     

    Publications

    1.      Yuan G#, Yang G#, Zheng Y, Zhu X, Chen Z, Zhang Z, Chen Y*. The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development. Development 2015, 142(1):128-39. [#Co-first author]

    2.      Yang G, Yuan G, Ye W, Cho KW, Chen Y*. An atypical canonical BMP signaling pathway regulates msh homeobox 1 (Msx1) expression during odontogenesis. J Biol Chem 2014, 289(45):31492-502.

    3.      Yang G, Li X, Yuan G, Liu P, Fan M*. The effects of Osterix on the proliferation and odontoblastic differentiation of human dental papilla cells. J Endod 2014, 40(11):1771-7.

    4.      Yang G#, Yuan G#, Li X, Liu P, Chen Z, Fan M*. BMP-2 induction of Dlx3 expression is meditated by p38/Smad5 signaling pathway in osteoblastic MC3T3-E1 cells. J Cell Physiol 2014, 229(7):943-54. [#Co-first author]

    5.      Yuan G, Zhang L, Yang G, Yang J, Wan C, Zhang L, Song G, Chen S, Chen Z. The distribution and ultrastructure of the forming blood capillaries and the effect of apoptosis on vascularization in mouse embryonic molar mesenchyme. Cell Tissue Res 2014, 356(1):137-45.

    6.      Yang GB, Li XY, Yuan GH, Liu H, Fan MW*. Immortalization and characterization of human dental papilla cells with odontoblastic differentiation. Int Endod J 2013, 46:565-72.

    7.      Li L, Wang Y, Lin M, Yuan G, Yang G, Zheng Y, Chen Y. Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation. PLoS One. 2013  8(6):e66107. 

    8.      Li X, Yang G#, Fan M*. Effects of homeobox gene distal-less 3 on proliferation and odontoblastic differentiation of human dental pulp cells. J Endod 2012, 38:1504-10. [#Co-first author]

    9.      Yuan G, Yang G#, Song G, Chen Z*, Chen S*. Immunohistochemical localization of the NH(2)-terminal and COOH-terminal fragments of dentin sialoprotein in mouse teeth. Cell Tissue Res 2012, 349:605-14. [#Co-first author]

    10.   Wang Y, Li L, Zheng Y, Yuan G, Yang G, He F, Chen Y*. BMP activity is required for tooth development from the lamina to bud stage. J Dent Res 2012, 91:690-5.

    11.   Yang G, Yuan G, Yun X, Zhou X, Liu B, Wu H. Effects of two nickel-titanium instrument systems, Mtwo versus ProTaper universal, on root canal geometry assessed by micro-computed tomography. J Endod. 2011;37:1412-6.

    12.   Feng J, Yang G, Yuan G, Gluhak-Heinrich J, Yang W, Wang L, Chen Z, Schulze McDaniel J, Donly KJ, Harris SE, Macdougall M, Chen S. Abnormalities in the enamel in bmp2-deficient mice. Cells Tissues Organs. 2011;194:216-21.

    13.   Yuan GH, Yang GB, Wu LA, Chen Z, Chen S.  Potential Role of Dentin Sialoprotein by Inducing Dental Pulp Mesenchymal Stem Cell Differentiation and Mineralization for Dental Tissue Repair.  Dent Hypotheses. 2010; 1:69-75.

    14.   Wu LA, Yuan G, Yang G, Ortiz-Gonzalez I, Yang W, Cui Y, MacDougall M, Donly KJ, Harris S, Chen S. Immortalization and characterization of mouse floxed Bmp2/4 osteoblasts. Biochem Biophys Res Commun. 2009; 386:89-95.

    15.   Yuan G, Wang Y, Gluhak-Heinrich J, Yang G, Chen L, Li T, Wu LA, Chen Z, MacDougall M, Chen S. Tissue-specific expression of dentin sialophosphoprotein (DSPP) and its polymorphisms in mouse tissues. Cell Biol Int. 2009; 33:816-29.

    16.   Yang GB, Wu HK, Zheng YL, Zhang H, Li HL, Zhou XD. Scanning electron microscopic evaluation of debris and smear layer remaining following use of ProTaper and Hero Shaper instruments in combination with NaOCl and EDTA irrigation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106:e63-71.

    17.   Yang GB, Zhou XD, Zheng YL, Zhang H, Shu Y, Wu HK. Shaping ability of progressive versus constant taper instruments in curved root canals of extracted teeth. Int Endod J 2007;40:707-14.