• Haojian Zhang
    • Professor,Ph.D
    • Phone No: 027-68750365
    • E-mail: haojian_zhang@whu.edu.cn

    Departments

    Research Field 

     ·Molecular mechanisms of cancer stem cell self-renewal and differentiation

     ·Molecular pathogenesis of hematological malignancies

    Education

      2008-2012 Ph.D.  University of Massachusetts Medical School, USA

      2006-2008       The Jackson Laboratory, USA

      2001-2004 M.S.   Institute of Zoology, Chinese Academy of Sciences, China

      1997-2001 B.S.   College of Life Science, Shandong Normal University, China 

    Professional Experience

      2016—present:  Professor, Wuhan University

      2012—2016: Research Fellow,Dana Farber Cancer Institute, Harvard Medical School

    Honors and Awards

      2016  Harvard Chinese Life Science YongJin Annual Distinguished Research Award

      2015  “1000 Young-Talented program”, China

      2013  Leukemia Lymphoma Society Fellow Award, USA

      2010  American Society of Hematology Annual Meeting Travel Award, USA

      2006-2008  “GSBS” Fellowship, The Jackson Laboratory, USA

    Publications

           1.     Xie XQ, Zhang H* (2016). Orphan drug development for targeting chronic myeloid leukemia stem cells. Expert Opinion on Orphan Drugs 8, 837-843. (*Corresponding author)

    2.     Zhang H*, Li S (2016). Induction of chronic myeloid leukemia in mice. Methods Mol. Bio. 1465: 17-25. (*Corresponding author)

    3.     Zhang H, Kozono D, O’Connor K, Vidal-Cardenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano E, Greenberger J, Bagby G, Soulier J, Grompe M, Parmar K, D’Andrea A (2016). TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia. Cell Stem Cell 18, 668-681.

    4.     Zhang H, Peng C, Zhi S, Hu Y, Li H, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Li D, Green M, Li S (2012). The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nature Genetics 44 (8): 861-871.

    5.     Zhang H*, Li S, Li H (2014). Management and orphan drugs development for acute myeloid leukemia. Expert Opinion on Orphan Drugs. 5:441-451. (*Corresponding author)

    6.     Zhang H, Li S (2013). Molecular Mechanisms for survival regulation of chronic myeloid leukemia stem cells. Protein Cell. 4:186-196.

    7.     Yang Z, Zhang H, Ma L, Peng C, Chen Y, Wang J, Green M, Li S, Rosmarin A (2013). Transcriptional factor GABP is required for hematopoietic stem cell cycling and development of chronic myeloid leukemia through regulating PRKD2 kinase. PNAS 110(6): 2312-7.

    8.     Zhang H, Li S (2013). DNA Microarray Assay Helps to Identify Functional Genes Specific for Leukemia Stem Cells. Dataset Papers in Science, Article ID 520285.

    9.     Ho N, Li A, Li S, Zhang H* (2012). Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies. Pharmaceuticals 5: 779-801. (*Corresponding author)

    10.  Zhang H, Li H, Ho N, Li D, Li S (2012). Scd1 plays a tumor suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia. Mol. Cell. Biol.  32:1776-1787. (Spotlight Article)

    11.  Zhang H, Li H, Xi H, Li S (2012). HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood 119(11): 2595-2607.

    12.  Peng C, Chen Y, Shan Y, Zhang H, Guo Z, Li D, Li S (2012). LSK derived LSK- cells have a high apoptotic rate related to surival regulation of hematopoietic and leukemia stem cells. PLoS One 7(6): e38614

    13.  Sullivan C, Chen Y, Shan Y, Hu Y, Peng C, Zhang H, Kong L, Li S (2011). Functional ramifications for the loss of p-selectin expression on hematopoietic and leukemic stem cells. PLoS One 2011 6 (10):e26246

    14.  Peng C, Chen Y, Yang Z, Zhang H, Osterby L, Rosamrin AG, Li S (2010). PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemia in mice. Blood 115:626-635.

    15.  Chen Y, Hu Y, Zhang H, Peng C, Li S (2009). Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nature Genetics. 41(7): 783-792.

    16.  Zhang H, Wang ZZ (2008). Mechanisms that mediate stem cell self-renewal and differentiation. J. Cell Biochem. 103(3): 709-718.

    17.  Yang YX, Miao ZC, Zhang H, Wang Y, Gao JX, Feng MF (2007). Establishment and characterization of a human telomerase catalytic submit-transduced fetal bone marrow-derived osteoblastic cell line. Differentiation 75 (1): 24-34.

    18.  Zhang H, Miao Z, He Z, Yang Y, Wang Y, Feng M (2005). The existence of epithelial-to-mesenchymal cells with the ability to support hematopoiesis in human fetal liver. Cell Biol. Int. 29 (3): 213-219.

    19.  He ZP, Tan WQ, Tang YF, Zhang H, Feng MF (2004). Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers. Cell Prolif. 37 (2):177-187.

    20.  Zhang H,Miao Z,Wang Y,Feng M (2004). Regulation of haematopoietic stem cells self-renenwal and the role of Wnt signaling in the process. Prog. Biochem. Biophys. 31 (7): 579-583.

    21.  Zhang H, He Z, Feng M (2004). Progress in fetal liver stem cell. Cell Biol. of Chin. 26 (1): 1-6.

    22. He Z, Zhang H, Wang Y, Wang J, Feng M (2003). Progress on plasticity of hepatic stem cells and the mechanisms governing their differentiation. Prog. Biochem. Biophys 30 (6): 864-867.