• Yufeng Zhang
    • Professor
    • Phone No: 027-87686222
    • E-mail: zyf@whu.edu.cn



    Research Field

    ·Periodontal Bone Regeneration

    ·Bone Substitute Biomaterials

    ·Clinical Trial in Dental Implantology

    ·Implant Surface


       · Ph.D. student from July 2002 to December 2006 , Majored in Dental Implantology, Supervised by Prof. Bin Shi and Prof. Xiangrong Cheng


    l Undergraduate student, from September 1997 to July 2002


    Oversea Study and Visit

    ·    September, 2008 — August, 2010 Queensland University of Technology, Postdoctoral Researchers

    ·    October, 2010 —October, 2011 University of Bern, Research Fellow

    Honors and Awards

    ·    National Nature Science Foundation of China. The mechanism of HnRNPL in Strontium induced osteogenesis. 81570954

    ·    National Nature Science Foundation of China. The molecular mechanism and application of Sema 4D in osteoporosis related maxillary bone remodeling, 81271108

    ·    Chinese Stomatological Association Award for young talents 3rd place nationwide, 2008

    ·    Outstanding Doctorate Dissertation Award, Hubei Province, 2008

    ·    Zhu Yubi Medical Prize, Wuhan University, 2010

    ·    New Century Excellent Talents in University of Ministry of Education of China,2011

    ·    Win Excellent Youth Foundation of Hubei,2011

    ·    Award for Science and Technology Progress of Hubei Province, the Second Prize, 2012

    ·    Natural Science Award of Hubei Province, the Second Prize, 2015


    1. Hu X, Wang Y, Tan Y, et al. A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer‐Directed Cell Recruitment. Advanced Materials, 2017 Feb, DOI:10.1002/adma.201605235.

    2. Yi S, Yu M, Yang S, Miron RJ, Zhang Y. Tcf12, A Member of Basic Helix‐Loop‐Helix Transcription Factors, Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation In Vitro and In Vivo. Stem Cells. 2017 Feb;35(2):386-397.

    3.      Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review. Tissue Eng Part B Rev. 2017 Feb;23(1):83-99.

    4. Fujioka‐Kobayashi M, Schaller B, Saulacic N, Zhang Y, Miron RJ. Growth factor delivery of BMP9 using a novel natural bovine bone graft with integrated atelo‐collagen type I: Biosynthesis, characterization, and cell behavior. Journal of Biomedical Materials Research Part A 2017;105:408-418.

    5. Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. Journal of periodontology 2017;88:112-121.

    6. Zhang Y, Yang S, Zhou W, Fu H, Qian L, Miron RJ. Addition of a synthetically fabricated osteoinductive biphasic calcium phosphate bone graft to BMP2 improves new bone formation. Clin Implant Dent Relat Res. 2016 Dec;18(6):1238-1247.

    7. Miron RJ, Zhang Q, Sculean A, et al. Osteoinductive potential of 4 commonly employed bone grafts. Clinical oral investigations 2016;20:2259-2265.

    8. Miron RJ, Shuang Y, Sculean A, Buser D, Chandad F, Zhang Y. Gene array of PDL cells exposed to Osteogain in combination with a bone grafting material. Clinical oral investigations 2016;20:2037-2043.

    9. Zhang Y, Ma Y, Wu C, Miron RJ, Cheng X. Platelet‐derived growth factor BB gene‐released scaffolds: biosynthesis and characterization. J Tissue Eng Regen Med. 2016 Oct;10(10):E372-E381.

    10. Shuang Y, Yizhen L, Zhang Y, Fujioka-Kobayashi M, Sculean A, Miron RJ. In vitro characterization of an osteoinductive biphasic calcium phosphate in combination with recombinant BMP2. BMC Oral Health 2016;17:35.

    11. Miron RJ, Sculean A, Cochran DL, et al. Twenty years of enamel matrix derivative: the past, the present and the future. Journal of clinical periodontology 2016;43:668-683.

    12. Zhang Y, Wei L, Miron RJ, Shi B, Bian Z. Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects. Scientific reports 2016;6:26925.

    13. Wang Y, Wan J, Miron RJ, Zhao Y, Zhang Y. Antibacterial properties and mechanisms of gold -silver nanocages. Nanoscale 2016;8:11143-11152.

    14. Wang Y, Zhang Y, Miron RJ. Health, maintenance, and recovery of soft tissues around implants. Clin Implant Dent Relat Res. 2016 Jun;18(3):618-34.

    15. Fujioka-Kobayashi M, Sawada K, Kobayashi E, Schaller B, Zhang Y, Miron RJ. Recombinant human bone morphogenetic protein 9 (rhbmp9) induced osteoblastic behavior on a collagen membrane compared with rhbmp2. Journal of periodontology 2016;87:e101-e107.

    16. Miron RJ, Sculean A, Shuang Y, et al. Osteoinductive potential of a novel biphasic calcium phosphate bone graft in comparison with autographs, xenografts, and DFDBA. Clin Oral Implants Res. 2016 Jun;27(6):668-75.

    17. Wang Y, Zhang Y, Jing D, Shuang Y, Miron RJ. Enamel matrix derivative improves gingival fibroblast cell behavior cultured on titanium surfaces. Clinical oral investigations 2016;20:685-695.

    18. Zhang Y, Jing D, Buser D, Sculean A, Chandad F, Miron RJ. Bone grafting material in combination with Osteogain for bone repair: a rat histomorphometric study. Clinical oral investigations 2016;20:589-595.

    19. Yin S, Ren W, Sun J, Zhang Y, Li M, Deng K. Hollow CDHA nanorods with mesopores on surface: Bi-micelle-templating method, dissolvability, cytocompatibility and protein delivery. Advanced Powder Technology 2016;27:199-206.

    20. Miron RJ, Chandad F, Buser D, Sculean A, Cochran DL, Zhang Y. Effect of enamel matrix derivative liquid on osteoblast and periodontal ligament cell proliferation and differentiation. Journal of periodontology 2016;87:91-99.

    21. Zhang Q, Chen X, Geng S, et al. Nanogel‐based scaffolds fabricated for bone regeneration with mesoporous bioactive glass and strontium: in vitro and in vivo characterization. J Biomed Mater Res A. 2016 Dec 20. doi: 10.1002/jbm.a.35980.

    22. Miron RJ, Shuang Y, Bosshardt DD, Caballé-Serrano J, Chandad F, Zhang Y. Osteogenic gene array of osteoblasts cultured on a novel osteoinductive biphasic calcium phosphate bone grafting material. Clin Oral Investig. 2016 Apr 23. doi:10.1007/s00784-016-1825-0.

    23. Fujioka‐Kobayashi M, Sawada K, Kobayashi E, Schaller B, Zhang Y, Miron RJ. Osteogenic potential of rhBMP9 combined with a bovine‐derived natural bone mineral scaffold compared to rhBMP2. Clin Oral Implants Res. 2016 Mar 14. doi: 10.1111/clr.12804.

    24. Miron RJ, Fujioka‐Kobayashi M, Zhang Y, et al. Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine‐derived natural bone mineral. Clin Oral Implants Res. 2016 Feb 26. doi: 10.1111/clr.12802.

    25. Zhang Y, Shuang Y, Fu H, et al. Characterization of a shorter recombinant polypeptide chain of bone morphogenetic protein 2 on osteoblast behaviour. BMC oral health 2015;15:171.

    26. Yang S, Lan L, Miron RJ, Wei L, Zhang M, Zhang Y. Variability in particle degradation of four commonly employed dental bone grafts. Clinical implant dentistry and related research 2015;17:996-1003.

    27. Miron RJ, Caluseru OM, Guillemette V, et al. Effect of bone graft density on in vitro cell behavior with enamel matrix derivative. Clinical oral investigations 2015;19:1643-1651.

    28. Dai J, Ma Y, Shi M, Cao Z, Zhang Y, Miron RJ. Initial changes in alveolar bone volume for sham-operated and ovariectomized rats in ligature-induced experimental periodontitis. Clinical oral investigations 2016;20:581-588.

    29. Wei L, Miron RJ, Shi B, Zhang Y. Osteoinductive and osteopromotive variability among different demineralized bone allografts. Clinical implant dentistry and related research 2015;17:533-542.

    30. Miron RJ, Bosshardt DD, Buser D, et al. Comparison of the capacity of enamel matrix derivative gel and enamel matrix derivative in liquid formulation to adsorb to bone grafting materials. Journal of periodontology 2015;86:578-587.

    31. Yang J-w, Zhang Y-f, Wan C-y, et al. Autophagy in SDF-1α-mediated DPSC migration and pulp regeneration. Biomaterials 2015;44:11-23.

    32. Zhang Y, Miron RJ, Li S, Shi B, Sculean A, Cheng X. Novel MesoPorous BioGlass/silk scaffold containing adPDGF‐B and adBMP7 for the repair of periodontal defects in beagle dogs. Journal of clinical periodontology 2015;42:262-271.

    33. Zhang Y, Wei L, Miron RJ, Shi B, Bian Z. Anabolic Bone Formation Via a Site‐Specific Bone‐Targeting Delivery System by Interfering With Semaphorin 4d Expression. Journal of Bone and Mineral Research 2015;30:286-296.

    34. Cao Z, Liu R, Zhang H, et al. Osterix controls cementoblast differentiation through downregulation of Wnt-signaling via enhancing DKK1 expression. International journal of biological sciences 2015;11:335.

    35. Chen X, Zhao Y, Geng S, et al. In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold. International journal of nanomedicine 2015;10:839.

    36. Zhang Y, Wei L, Miron R, Zhang Q, Bian Z. Prevention of alveolar bone loss in an osteoporotic animal model via interference of semaphorin 4d. Journal of dental research 2014;93:1095-1100.

    37. Miron RJ, Wei L, Yang S, Caluseru OM, Sculean A, Zhang Y. Effect of enamel matrix derivative on periodontal wound healing and regeneration in an osteoporotic model. Journal of periodontology 2014;85:1603-1611.

    38. Liao L, Yang S, Miron RJ, Wei J, Zhang Y, Zhang M. Osteogenic properties of PBLG-g-HA/PLLA nanocomposites. PloS one 2014;9:e105876.

    39. Wei L, Ke J, Prasadam I, et al. A comparative study of Sr-incorporated mesoporous bioactive glass scaffolds for regeneration of osteopenic bone defects. Osteoporosis International 2014;25:2089-2096.

    40. Zhang Y, Wei L, Wu C, Miron RJ. Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats. PloS one 2014;9:e104527.

    41. Yang S, Miron RJ, Wei J, Zhang Y. In vitro characterization of PBLG-g-HA/PLLA nanocomposite scaffolds. Journal of Wuhan University of Technology-Mater Sci Ed 2014;29:841-847.

    42. Miron RJ, Guillemette V, Zhang Y, Chandad F, Sculean A. Enamel matrix derivative in combination with bone grafts: A review of the literature. Quintessence Int 2014;45:475-487.

    43. Zhao J, Wang X, Kuang Y, et al. Multilayer composite beads constructed via layer-by-layer self-assembly for lysozyme controlled release. RSC Advances 2014;4:24369-24376.

    44. Su M, Shi B, Zhu Y, et al. Comparison of implant success rates with different loading protocols: a meta-analysis. Int J Oral Maxillofac Implants. 2014 Mar-Apr;29(2):344-52.

    45. Miron RJ, Wei L, Bosshardt DD, Buser D, Sculean A, Zhang Y. Effects of enamel matrix proteins in combination with a bovine-derived natural bone mineral for the repair of bone defects. Clinical oral investigations 2014;18:471-478.

    46. Dai J, Cheng N, Miron RJ, Shi B, Cheng X, Zhang Y. Effect of decreased implant healing time on bone (re) modeling adjacent to plateaued implants under functional loading in a dog model. Clinical oral investigations 2014;18:77-86.

    47. Zhang Y, Li S, Wu C. The in vitro and in vivo cementogenesis of CaMgSi2O6 bioceramic scaffolds. Journal of Biomedical Materials Research Part A 2014;102:105-116.

    48. Cheng N, Wang Y, Zhang Y, Shi B. The osteogenic potential of mesoporous bioglasses/silk and non-mesoporous bioglasses/silk scaffolds in ovariectomized rats: in vitro and in vivo evaluation. PloS one 2013;8:e81014.

    49. Cheng N, Dai J, Cheng X, et al. Porous CaP/silk composite scaffolds to repair femur defects in an osteoporotic model. Journal of Materials Science: Materials in Medicine 2013;24:1963-1975.

    50. Miron RJ, Caluseru OM, Guillemette V, et al. Influence of enamel matrix derivative on cells at different maturation stages of differentiation. PLoS One 2013;8:e71008.

    51. Miron RJ, Gruber R, Hedbom E, et al. Impact of bone harvesting techniques on cell viability and the release of growth factors of autografts. Clinical implant dentistry and related research 2013;15:481-489.

    52. Zhang Y, Wei L, Chang J, et al. Strontium-incorporated mesoporous bioactive glass scaffolds stimulating in vitro proliferation and differentiation of bone marrow stromal cells and in vivo regeneration of osteoporotic bone defects. Journal of Materials Chemistry B 2013;1:5711-5722.

    53. Wu C, Chen L, Chang J, Wei L, Chen D, Zhang Y. Porous nagelschmidtite bioceramic scaffolds with improved in vitro and in vivo cementogenesis for periodontal tissue engineering. RSC Advances 2013;3:17843-17850.

    54. Wang R, Liu Z, Zhang Y. The behavior of new hydrophilic composite bone cements for immediate loading of dental implant. Journal of Wuhan University of Technology-Mater Sci Ed 2013;28:627-633.


    56. Xu M, Zhang Y, Zhai D, Chang J, Wu C. Mussel-inspired bioactive ceramics with improved bioactivity, cell proliferation, differentiation and bone-related gene expression of MC3T3 cells. Biomaterials Science 2013;1:933-941.

    57. Miron RJ, Bosshardt DD, Zhang Y, Buser D, Sculean A. Gene array of primary human osteoblasts exposed to enamel matrix derivative in combination with a natural bone mineral. Clinical oral investigations 2013;17:405-410.

    58. Zhang Y, Zhang X, Shi B, Miron R. Membranes for guided tissue and bone regeneration. Annals of Oral & Maxillofacial Surgery 2013;1:10.

    59. Zhang Y, Cheng N, Miron R, Shi B, Cheng X. Delivery of PDGF-B and BMP-7 by mesoporous bioglass/silk fibrin scaffolds for the repair of osteoporotic defects. Biomaterials 2012;33:6698-6708.

    60. Shue L, Yufeng Z, Mony U. Biomaterials for periodontal regeneration: a review of ceramics and polymers. Biomatter 2012;2:271-277.

    61. Zhang Y, Wu C, Luo T, Li S, Cheng X, Miron RJ. Synthesis and inflammatory response of a novel silk fibroin scaffold containing BMP7 adenovirus for bone regeneration. Bone 2012;51:704-713.

    62. Luo T, Wu C, Zhang Y. The in vivo osteogenesis of Mg or Zr‐modified silicate‐based bioceramic spheres. Journal of Biomedical Materials Research Part A 2012;100:2269-2277.

    63. Miron R, Zhang Y. Osteoinduction a review of old concepts with new standards. Journal of dental research 2012;91:736-744.

    64. Miron RJ, D. Bosshardt D, Hedbom E, et al. Adsorption of enamel matrix proteins to a bovine-derived bone grafting material and its regulation of cell adhesion, proliferation, and differentiation. Journal of periodontology 2012;83:936-947.

    65. Du X, Huang X, Huang C, Wang Y, Zhang Y. Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive. Journal of dentistry 2012;40:485-492.

    66. Luo T, Zhang W, Shi B, Cheng X, Zhang Y. Enhanced bone regeneration around dental implant with bone morphogenetic protein 2 gene and vascular endothelial growth factor protein delivery. Clinical oral implants research 2012;23:467-473.

    67. Miron R, Hedbom E, Saulacic N, et al. Osteogenic potential of autogenous bone grafts harvested with four different surgical techniques. Journal of dental research 2011;90:1428-1433.

    68. Wu C, Miron R, Sculean A, et al. Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds. Biomaterials 2011;32:7068-7078.

    69. Zhu Y, Zhang Y, Wu C, Fang Y, Yang J, Wang S. The effect of zirconium incorporation on the physiochemical and biological properties of mesoporous bioactive glasses scaffolds. Microporous and Mesoporous Materials 2011;143:311-319.

    70. Wu C, Zhang Y, Fan W, et al. CaSiO3 microstructure modulating the in vitro and in vivo bioactivity of poly (lactide‐co‐glycolide) microspheres. Journal of Biomedical Materials Research Part A 2011;98:122-131.

    71. Zhang Y, Fan W, Nothdurft L, et al. In vitro and in vivo evaluation of adenovirus combined silk fibroin scaffolds for bone morphogenetic protein-7 gene delivery. Tissue Engineering Part C: Methods 2011;17:789-797.

    72. Miron RJ, Hedbom E, Ruggiero S, et al. Premature osteoblast clustering by enamel matrix proteins induces osteoblast differentiation through up-regulation of connexin 43 and N-cadherin. PloS one 2011;6:e23375.

    73. Wu C, Zhang Y, Zhou Y, Fan W, Xiao Y. A comparative study of mesoporous glass/silk and non-mesoporous glass/silk scaffolds: physiochemistry and in vivo osteogenesis. Acta biomaterialia 2011;7:2229-2236.

    74. Wu C, Zhang Y, Ke X, et al. Bioactive mesopore‐glass microspheres with controllable protein‐delivery properties by biomimetic surface modification. Journal of Biomedical Materials Research Part A 2010;95:476-485.

    75. Zhang Y, Fan W, Ma Z, et al. The effects of pore architecture in silk fibroin scaffolds on the growth and differentiation of mesenchymal stem cells expressing BMP7. Acta biomaterialia 2010;6:3021-3028.

    76. Yang L, Zhang Y, Dong R, et al. Effects of adenoviral‐mediated coexpression of bone morphogenetic protein‐7 and insulin‐like growth factor‐1 on human periodontal ligament cells. Journal of periodontal research 2010;45:532-540.

    77. Wu C, Zhu Y, Chang J, Zhang Y, Xiao Y. Bioactive inorganic‐materials/alginate composite microspheres with controllable drug‐delivery ability. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2010;94:32-43.

    78. Ma Z, Wang J, Zhang L, Zhang Y, Ding K. Evaluation of water soluble β-D-glucan from Auricularia auricular-judae as potential anti-tumor agent. Carbohydrate Polymers 2010;80:977-983.

    79. Wu C, Zhang Y, Zhu Y, Friis T, Xiao Y. Structure -property relationships of silk-modified mesoporous bioglass scaffolds. Biomaterials 2010;31:3429-3438.

    80. Zhang Y, Wu C, Friis T, Xiao Y. The osteogenic properties of CaP/silk composite scaffolds. Biomaterials 2010;31:2848-2856.

    81. Luo L-H, Zhang Y-F, Wang X-M, et al. Preparation, characterization, and in vitro and in vivo evaluation of cellulose/soy protein isolate composite sponges. J Biomater Appl. 2010 Feb;24(6):503-26.

    82. Zhang Y, Shi B, Li C, et al. The synergetic bone-forming effects of combinations of growth factors expressed by adenovirus vectors on chitosan/collagen scaffolds. Journal of Controlled Release 2009;136:172-178.

    83. Shi S, Cheng X, Wang J, Zhang W, Peng L, Zhang Y. RhBMP-2 microspheres-loaded chitosan/collagen scaffold enhanced osseointegration: an experiment in dog. J Biomater Appl. 2009 Jan;23(4):331-46.

    84. Luo L-H, Wang X-M, Zhang Y-F, et al. Physical properties and biocompatibility of cellulose/soy protein isolate membranes coagulated from acetic aqueous solution. Journal of Biomaterials Science, Polymer Edition 2008;19:479-496.

    85. Zhang Y, Song J, Shi B, et al. Combination of scaffold and adenovirus vectors expressing bone morphogenetic protein-7 for alveolar bone regeneration at dental implant defects. Biomaterials 2007;28:4635-4642.

    86. Ke J, Liu Y, Long X, et al. Up‐regulation of vascular endothelial growth factor in synovial fibroblasts from human temporomandibular joint by hypoxia. Journal of oral pathology & medicine 2007;36:290-296.

    87. Ke J, Long X, Liu Y, et al. Role of NF-κB in TNF-α-induced COX-2 Expression in Synovial Fibroblasts from Human TMJ. Journal of dental research 2007;86:363-367.

    88. Zhang Y, Wang Y, Shi B, Cheng X. A platelet-derived growth factor releasing chitosan/coral composite scaffold for periodontal tissue engineering. Biomaterials 2007;28:1515-1522.

    89. Zhang Y, Cheng X, Wang J, et al. Novel chitosan/collagen scaffold containing transforming growth factor-β1 DNA for periodontal tissue engineering. Biochemical and biophysical research communications 2006;344:362-369.

    90. Zhang Y-F, Cheng X-R, Chen Y, et al. Three-dimensional nanohydroxyapatite/chitosan scaffolds as potential tissue engineered periodontal tissue. Journal of biomaterials applications 2007;21:333-349.