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Follicle stimulating hormone (FSH) has a significant impacton adiposeenergy metabolism.

2017-06-09

Recently, a cooperation research paper made by Mount Sinai School of Medicine and Wuhan University School of Stomatology was published in top Journal . This study found that follicle stimulating hormone (FSH) has a significant impacton adiposeenergy metabolism.

Dr. JiYaoting (School & Hospital of Stomatology, Wuhan University) is the co-first author of this paper and Professor Mone Zaidi as the corresponding author.

Endocrine hormones changes, estrogen (E2) and high follicle stimulating hormone (FSH), during menopausal affect the basal metabolism of the body. Studies have shown that the postmenopausal high levels of FSH promoted bone resorption through enhancement of osteoclasts function which cause osteoporosis. Meanwhile FSH could directly regulateadipose metabolism by affecting adipocyte differentiation/maturation through its receptor (FSHR).

Considering that, the researchers designed a specific antibody against FSH to block its action. Previous studies have shown that this anti-FSH antibody block FSH action on the osteoclastsin vitro. And in vivo study proved its role in osteoporosis prevention and treatment. This study further showed that the antibody can significantly reduce the accumulation of visceral fat in high fat diet-induced mice and ovariectomized mice. Using the transgenic mice (Thermo mice, UCP1-Luci), they found that the beige cellswas activated and increase the basal metabolism.

This study is an important discovery in endocrine and metabolic research, which is expected to promote the development of a single drug treatment of osteoporosisand weight gainaftermenopause, as well as general obesity. It also provides theoretical and practical basis for diseases involving other visceral fats, such as metabolic syndrome, cardiovascular disease, cancer, diabetes and polycystic ovarian disease.

This achievement was supported by National Natural Science Foundation of China, International (regional) cooperationproject (To Prof. ZhuanBian, Wuhan University School of Stomatology, and Prof. Mone Zaidi, Mount Sinai School of Medicine), Young people top-notch talent project and the related projects of National Institutes of Health (NIH, US).


 

The structural modeling of FSH/FSHR interaction

The antibody can significantly reduce the accumulation of visceral fat in high fat diet-induced mice